My colleagues Robert Rice and Seth Rowland recently reported problems with Outlook links to Time Matters and Credenza not working, even though everything was setup properly and appeared to be active.
Upon closer inspection Outlook was found to be in Safe Mode.
The problem was traced to a recent update KB3114409. Uninstalling the update seems to cure the problem.
If you are having this problem please speak with your IT about uninstalling the update.
Note this update was designed for Outlook 2010 and has been pulled by Microsoft.